2/28/2024 0 Comments Tcr sequenceTumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. Simultaneous detection of many T-cell specificities using combinatorial tetramer staining. Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers. A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells. Preparation of peptide-MHC and T-cell receptor dextramers by biotinylated dextran doping. Dipeptides catalyze rapid peptide exchange on MHC class I molecules. Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7. Design and use of conditional MHC class I ligands. Mycobacterium tuberculosis-specific CD4 + and CD8 + T cells differ in their capacity to recognize infected macrophages. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Tricks with tetramers: how to get the most from multimeric peptide-MHC. Tracking T cells with tetramers: new tales from new tools. More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers. This study described the use of pMHC tetramers for identification and characterization of antigen-specific T lymphocytes.ĭolton, G. Phenotypic analysis of antigen-specific T lymphocytes. High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4 + T cells in human melanoma. Single-chain HLA-A2 MHC trimers that incorporate an immunodominant peptide elicit protective T cell immunity against lethal West Nile virus infection. Cutting edge: single-chain trimers of MHC class I molecules form stable structures that potently stimulate antigen-specific T cells and B cells. Y., Netuschil, N., Lybarger, L., Connolly, J. targets with epitope-linked beta 2-microglobulin constructs. A single-chain murine class I major transplantation antigen. Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope. T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable. A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus. Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants. A sensitive ELISPOT assay to detect low-frequency human T lymphocytes. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. Isolation and characterization of NY-ESO-1-specific T cell receptors restricted on various MHC molecules. Human neoplasms elicit multiple specific immune responses in the autologous host. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. 21, constitutes pioneering T cell antigen-discovery work that identified several classic melanoma antigens. This study, along with that of van der Bruggen et al. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity. NetMHCpan-4.0: improved peptide-MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data. Alternative mRNA splicing in cancer immunotherapy. In vitro evolution of a T cell receptor with high affinity for peptide/MHC. Polyspecificity of T cell and B cell receptor recognition. A single autoimmune T cell receptor recognizes more than a million different peptides. Discovery of T cell antigens by high-throughput screening of synthetic minigene libraries. A very high level of crossreactivity is an essential feature of the T-cell receptor. The many important facets of T-cell repertoire diversity. Codification of bidentate pMHC interaction with TCR and its co-receptor. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Present yourself! By MHC class I and MHC class II molecules. Unconventional T cell targets for cancer immunotherapy. T-cell development and the CD4-CD8 lineage decision. The cellular immunotherapy revolution: arming the immune system for precision therapy. Overlap and effective size of the human CD8 + T cell receptor repertoire. Understanding the drivers of MHC restriction of T cell receptors. T-cell antigen receptor genes and T-cell recognition.
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